The observations indicate that non-sedating antihistamines, as opposed to what has been thought previously, may be helpful in patients with allergic rhinitis in whom nasal obstruction is a major concern.Current international guidelines need to be revised in the light of the recent evidence.Nonsteroidal anti-inflammatory drugs (usually abbreviated to NSAIDs), are a drug class that groups together drugs that decrease pain and lower fever, and, in higher doses decrease inflammation.The most prominent members of this group of drugs, aspirin, ibuprofen and naproxen, are all available over the counter in most countries. The cyclooxygenase enzyme inhibited by NSAIDs was discovered to have at least 2 different versions: COX1 and COX2.
Antihistamines block the action of histamine, and histamine-related symptoms include: Other symptoms, including post-nasal drip, cough, and nasal congestion may also be caused by histamine, and therefore can be treated by antihistamines.Some sedatives can cause psychological and physical dependence when taken regularly over a period of time, even at therapeutic doses.Dependent users may get withdrawal symptoms ranging from restlessness and insomnia to convulsions and death. Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.